Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors
Abstract GPR139 is a Gq‐coupled receptor activated by the essential amino acids L‐tryptophan (L‐Trp) and L‐phenylalanine (L‐Phe). We carried out mutagenesis studies of the human GPR139 receptor to identify the critical structural motifs required for GPR139 activation. We applied site‐directed and hi...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2019-02-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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