Fabrication of Core Crosslinked Polymeric Micelles as Nanocarriers for Doxorubicin Delivery: Self-Assembly, <i>In Situ</i> Diselenide Metathesis and Redox-Responsive Drug Release

• Main Authors: Yihenew Simegniew Birhan (Author), Haile Fentahun Darge (Author), Endiries Yibru Hanurry (Author), Abegaz Tizazu Andrgie (Author), Tefera Worku Mekonnen (Author), Hsiao-Ying Chou (Author), Juin-Yih Lai (Author), Hsieh-Chih Tsai (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polymeric micelles (PMs) have been used to improve the poor aqueous solubility, slow absorption and non-selective biodistribution of chemotherapeutic agents (CAs), albeit, they suffer from disassembly and premature release of payloads in the bloodstream. To alleviate the thermodynamic instability of...