The Regulation of Human β-Defensin 2 by the ETS Transcription Factor MEF (Myeloid Elf-1-Like Factor) Is Enhanced by Promyelocytic Leukemia Protein

• Main Authors: Mary Ann Suico (Author), Zhuo Lu (Author), Tsuyoshi Shuto (Author), Tomoaki Koga (Author), Tomoko Uchikawa (Author), Hiroki Yoshida (Author), Kazuhito Matsuzaki (Author), Mitsuyoshi Nakao (Author), Jian-Dong Li (Author), Hirofumi Kai (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human β-defensin 2 (HBD 2) is a potent anti-bacterial peptide with a wide spectrum of activity. MEF (myeloid elf-1-like factor) or Elf4, a member of the ETS transcription factor family, has been shown to up-regulate the basal expression of the HBD 2 gene in epithelial cells. The mammalian cell n...