Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

• المؤلفون الرئيسيون: Ulyana Boyarskikh (مؤلف), Sergey Pintus (مؤلف), Nikita Mandrik (مؤلف), Daria Stelmashenko (مؤلف), Ilya Kiselev (مؤلف), Ivan Evshin (مؤلف), Ruslan Sharipov (مؤلف), Philip Stegmaier (مؤلف), Fedor Kolpakov (مؤلف), Maxim Filipenko (مؤلف), Alexander Kel (مؤلف)
• التنسيق: كتاب
• منشور في: BMC, 2018-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Small molecule Nutlin-3 reactivates p53 in cancer cells by interacting with the complex between p53 and its repressor Mdm-2 and causing an increase in cancer cell apoptosis. Therefore, Nutlin-3 has potent anticancer properties. Clinical and experimental studies of Nutlin-3 showed...