Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

• Main Authors: Ulyana Boyarskikh (Author), Sergey Pintus (Author), Nikita Mandrik (Author), Daria Stelmashenko (Author), Ilya Kiselev (Author), Ivan Evshin (Author), Ruslan Sharipov (Author), Philip Stegmaier (Author), Fedor Kolpakov (Author), Maxim Filipenko (Author), Alexander Kel (Author)
• Format: Book
• Published: BMC, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Small molecule Nutlin-3 reactivates p53 in cancer cells by interacting with the complex between p53 and its repressor Mdm-2 and causing an increase in cancer cell apoptosis. Therefore, Nutlin-3 has potent anticancer properties. Clinical and experimental studies of Nutlin-3 showed...