1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one inhibits SARS-CoV-2 by targeting the nucleocapsid protein

• Main Authors: Yang Liu (Author), Kuiru Sa (Author), Wei Xu (Author), Yongkang Chen (Author), Jing Liang (Author), Peng Zou (Author), Lixia Chen (Author)
• Format: Book
• Published: Compuscript Ltd, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally since 2020. The nucleocapsid (N) protein plays a crucial role in the life cycle of SARS-CoV-2. Here, we established a method to screen inhibitors of N protein by using microscale thermophoresis assays to obtain potentia...