Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine

• Main Authors: Stefano Vitello (Author), Italia Di Liegro (Author), Maria Rita Ricciardi (Author), Chiara Verga (Author), Alessandra Amato (Author), Gabriella Schiera (Author), Carlo Di Liegro (Author), Giuseppe Messina (Author), Patrizia Proia (Author)
• Format: Book
• Published: PAGEPress Publications, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumorigenesis is a multiphasic process in which genetic alterations guide the progressive transformation in cancer cells1. In order to evaluate the possible correlation between some gene variants and the risk of the toxicity development onset, two of the polymorphisms of the thymidylate synthase (TY...