PK Modeling of L-4-Boronophenylalanine and Development of Bayesian Predictive Platform for L-4-Boronophenylalanine PKs for Boron Neutron Capture Therapy

• Glavni autori: Woohyoung Kim (Autor), Ji Yeong Won (Autor), Jungyu Yi (Autor), Seung Chan Choi (Autor), Sang Min Lee (Autor), Kyungran Mun (Autor), Hyeong-Seok Lim (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2024-02-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

L-4-[(¹⁰B)]Boronophenylalanine (BPA) is an amino acid analogue with a boron-10 moiety. It is most widely used as a boron carrier in boron neutron capture therapy. In this study, a Bayesian predictive platform of blood boron concentration based on a BPA pharmacokinetic (PK) mod...