PK Modeling of L-4-Boronophenylalanine and Development of Bayesian Predictive Platform for L-4-Boronophenylalanine PKs for Boron Neutron Capture Therapy

• Hoofdauteurs: Woohyoung Kim (Auteur), Ji Yeong Won (Auteur), Jungyu Yi (Auteur), Seung Chan Choi (Auteur), Sang Min Lee (Auteur), Kyungran Mun (Auteur), Hyeong-Seok Lim (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2024-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

L-4-[(¹⁰B)]Boronophenylalanine (BPA) is an amino acid analogue with a boron-10 moiety. It is most widely used as a boron carrier in boron neutron capture therapy. In this study, a Bayesian predictive platform of blood boron concentration based on a BPA pharmacokinetic (PK) mod...