PK Modeling of L-4-Boronophenylalanine and Development of Bayesian Predictive Platform for L-4-Boronophenylalanine PKs for Boron Neutron Capture Therapy

• Main Authors: Woohyoung Kim (Author), Ji Yeong Won (Author), Jungyu Yi (Author), Seung Chan Choi (Author), Sang Min Lee (Author), Kyungran Mun (Author), Hyeong-Seok Lim (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

L-4-[(¹⁰B)]Boronophenylalanine (BPA) is an amino acid analogue with a boron-10 moiety. It is most widely used as a boron carrier in boron neutron capture therapy. In this study, a Bayesian predictive platform of blood boron concentration based on a BPA pharmacokinetic (PK) mod...