Development of a PBPK model to quantitatively understand absorption and disposition mechanism and support future clinical trials for PB‐201

• Main Authors: Miao Zhang (Author), Zihan Lei (Author), Ziheng Yu (Author), Xueting Yao (Author), Haiyan Li (Author), Min Xu (Author), Dongyang Liu (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract PB‐201 is the second glucokinase activator in the world to enter the phase III clinical trials for the treatment of type 2 diabetes mellitus (T2DM). Combined with the efficacy advantages and the friendly absorption, distribution, metabolism, and excretion characteristics, the indication pop...