Development of a PBPK model to quantitatively understand absorption and disposition mechanism and support future clinical trials for PB‐201

• Päätekijät: Miao Zhang (Tekijä), Zihan Lei (Tekijä), Ziheng Yu (Tekijä), Xueting Yao (Tekijä), Haiyan Li (Tekijä), Min Xu (Tekijä), Dongyang Liu (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Wiley, 2023-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract PB‐201 is the second glucokinase activator in the world to enter the phase III clinical trials for the treatment of type 2 diabetes mellitus (T2DM). Combined with the efficacy advantages and the friendly absorption, distribution, metabolism, and excretion characteristics, the indication pop...