Calcium and Reactive Oxygen Species Mediated Zn2+-Induced Apoptosis in PC12 Cells

• Main Authors: Shinji Abe (Author), Hideki Ohnishi (Author), Koichiro Tsuchiya (Author), Keisuke Ishizawa (Author), Mayumi Torii (Author), Yasuhisa Kanematsu (Author), Kazuyoshi Kawazoe (Author), Kazuo Minakuchi (Author), Masanori Yoshizumi (Author), Toshiaki Tamaki (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The release of excessive Zn2+ from presynaptic boutons into extracellular regions contributes to neuronal apoptotic events, which result in neuronal cell death. However, the mechanisms of Zn2+-induced neuronal cell death are still unclear. Therefore, we investigated the dynamics of intracellular Zn2...