Improving single nucleotide polymorphisms genotyping accuracy for dihydropyrimidine dehydrogenase testing in pharmacogenetics

• 主要な著者: Annalaura Montella (著者), Sueva Cantalupo (著者), Giuseppe D'Alterio (著者), Vincenzo Damiano (著者), Achille Iolascon (著者), Mario Capasso (著者)
• フォーマット: 図書
• 出版事項: Open Exploration Publishing Inc., 2024-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Fluoropyrimidines, crucial in cancer treatment, often cause toxicity concerns even at standard doses. Toxic accumulation of fluoropyrimidine metabolites, culminating in adverse effects, can stem from impaired dihydropyrimidine dehydrogenase (DPYD) enzymatic function. Emerging evidence underscores th...