Improving single nucleotide polymorphisms genotyping accuracy for dihydropyrimidine dehydrogenase testing in pharmacogenetics

• Main Authors: Annalaura Montella (Author), Sueva Cantalupo (Author), Giuseppe D'Alterio (Author), Vincenzo Damiano (Author), Achille Iolascon (Author), Mario Capasso (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fluoropyrimidines, crucial in cancer treatment, often cause toxicity concerns even at standard doses. Toxic accumulation of fluoropyrimidine metabolites, culminating in adverse effects, can stem from impaired dihydropyrimidine dehydrogenase (DPYD) enzymatic function. Emerging evidence underscores th...