Pharmacokinetic/Pharmacodynamic Analysis and Dose Optimization of Cefmetazole and Flomoxef against Extended-Spectrum β-Lactamase-Producing <i>Enterobacterales</i> in Patients with Invasive Urinary Tract Infection Considering Renal Function

• Main Authors: Yukihiro Hamada (Author), Hidefumi Kasai (Author), Moeko Suzuki-Ito (Author), Yasufumi Matsumura (Author), Yohei Doi (Author), Kayoko Hayakawa (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The optimal regimens of cefmetazole and flomoxef for the treatment of urinary tract infections caused by extended-spectrum β-lactamase (ESBL)-producing <i>Enterobacterales</i> are not well defined. Our study found that the pharmacokinetic/pharmacodynamic targets for cefmetazole and flomo...