All-potassium channel CRISPR screening reveals a lysine-specific pathway of insulin secretion

• Prif Awduron: Jing Lu (Awdur), Ru-Xuan Zhao (Awdur), Feng-Ran Xiong (Awdur), Juan-Juan Zhu (Awdur), Ting-Ting Shi (Awdur), Ying-Chao Zhang (Awdur), Gong-Xin Peng (Awdur), Jin-Kui Yang (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2024-02-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Objective: Genome-scale CRISPR-Cas9 knockout coupled with single-cell RNA sequencing (scRNA-seq) has been used to identify function-related genes. However, this method may knock out too many genes, leading to low efficiency in finding genes of interest. Insulin secretion is controlled by several ele...