Roles and inhibitors of FAK in cancer: current advances and future directions

• Главные авторы: Hui-Hui Hu (Автор), Sai-Qi Wang (Автор), Hai-Li Shang (Автор), Hui-Fang Lv (Автор), Bei-Bei Chen (Автор), She-Gan Gao (Автор), Xiao-Bing Chen (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that exhibits high expression in various tumors and is associated with a poor prognosis. FAK activation promotes tumor growth, invasion, metastasis, and angiogenesis via both kinase-dependent and kinase-independent pathways. Moreover, FAK...