Roles and inhibitors of FAK in cancer: current advances and future directions

• Main Authors: Hui-Hui Hu (Author), Sai-Qi Wang (Author), Hai-Li Shang (Author), Hui-Fang Lv (Author), Bei-Bei Chen (Author), She-Gan Gao (Author), Xiao-Bing Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that exhibits high expression in various tumors and is associated with a poor prognosis. FAK activation promotes tumor growth, invasion, metastasis, and angiogenesis via both kinase-dependent and kinase-independent pathways. Moreover, FAK...