Exploring the therapeutic potential of sγPNA-141: Pharmacodynamics and mechanistic insights during ischemic stroke recovery

• Главные авторы: Sanjeev Kumar Yadav (Автор), Karishma Dhuri (Автор), Daylin Gamiotea-Turro (Автор), Mary-Katherine Cormier (Автор), Vraj Patel (Автор), Arun Kumar Yadawa (Автор), Mounika Pathuri (Автор), Raman Bahal (Автор), Rajkumar Verma (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2024-12-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

MicroRNA-141-3p plays a detrimental role in the pathology of ischemic stroke, presenting a new target for stroke treatment. This study introduces and validates a novel class of peptide nucleic acid (PNA)-based miR-141-3p inhibitors known as serine gamma PNA-141 (sγPNA-141) for ischemic stroke treatm...