Exploring the therapeutic potential of sγPNA-141: Pharmacodynamics and mechanistic insights during ischemic stroke recovery

• Main Authors: Sanjeev Kumar Yadav (Author), Karishma Dhuri (Author), Daylin Gamiotea-Turro (Author), Mary-Katherine Cormier (Author), Vraj Patel (Author), Arun Kumar Yadawa (Author), Mounika Pathuri (Author), Raman Bahal (Author), Rajkumar Verma (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNA-141-3p plays a detrimental role in the pathology of ischemic stroke, presenting a new target for stroke treatment. This study introduces and validates a novel class of peptide nucleic acid (PNA)-based miR-141-3p inhibitors known as serine gamma PNA-141 (sγPNA-141) for ischemic stroke treatm...