Exploring the therapeutic potential of sγPNA-141: Pharmacodynamics and mechanistic insights during ischemic stroke recovery

• Auteurs principaux: Sanjeev Kumar Yadav (Auteur), Karishma Dhuri (Auteur), Daylin Gamiotea-Turro (Auteur), Mary-Katherine Cormier (Auteur), Vraj Patel (Auteur), Arun Kumar Yadawa (Auteur), Mounika Pathuri (Auteur), Raman Bahal (Auteur), Rajkumar Verma (Auteur)
• Format: Livre
• Publié: Elsevier, 2024-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

MicroRNA-141-3p plays a detrimental role in the pathology of ischemic stroke, presenting a new target for stroke treatment. This study introduces and validates a novel class of peptide nucleic acid (PNA)-based miR-141-3p inhibitors known as serine gamma PNA-141 (sγPNA-141) for ischemic stroke treatm...