Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages

• Main Authors: Etta Y.L. Liu (Author), Yingjie Xia (Author), Xiangpeng Kong (Author), Maggie S.S. Guo (Author), Anna X.D. Yu (Author), Brody Z.Y. Zheng (Author), Shinghung Mak (Author), Miranda L. Xu (Author), Karl W.K. Tsim (Author)
• Format: Book
• Published: Elsevier, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetylcholine (ACh) regulates inflammation via α7 nicotinic acetylcholine receptor (α7 nAChR). Acetylcholinesterase (AChE), an enzyme hydrolyzing ACh, is expressed in immune cells suggesting non-classical function in inflammatory responses. Here, the expression of PRiMA-linked G4 AChE was identified...