Specific knockdown of Htra2 by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice

• Egile Nagusiak: Yang Guo (Egilea), Lei Han (Egilea), Shuang Han (Egilea), Honghai Tang (Egilea), Shengyi Wang (Egilea), Chong Cui (Egilea), Bing Chen (Egilea), Huawei Li (Egilea), Yilai Shu (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2022-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

CasRx, a recently discovered member of the type VI CRISPR system with minimum size, offers a new approach for RNA manipulation with high efficiency and specificity in prokaryotes and eukaryotes. However, in vivo studies of functional recovery using the CasRx system have not been well characterized....