Specific knockdown of Htra2 by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice

• Main Authors: Yang Guo (Author), Lei Han (Author), Shuang Han (Author), Honghai Tang (Author), Shengyi Wang (Author), Chong Cui (Author), Bing Chen (Author), Huawei Li (Author), Yilai Shu (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CasRx, a recently discovered member of the type VI CRISPR system with minimum size, offers a new approach for RNA manipulation with high efficiency and specificity in prokaryotes and eukaryotes. However, in vivo studies of functional recovery using the CasRx system have not been well characterized....