Tissue pharmacokinetics of antisense oligonucleotides
Pharmacokinetics (PK) of antisense oligonucleotides (ASOs) is characterized by rapid distribution from plasma to tissue and slow terminal plasma elimination driven by re-distribution from tissue. Quantitative understanding of tissue PK and RNA knockdown for various ASO chemistries, conjugations, and...
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Main Authors: | Erica Bäckström (Author), Alessandro Bonetti (Author), Per Johnsson (Author), Stefan Öhlin (Author), Anders Dahlén (Author), Patrik Andersson (Author), Shalini Andersson (Author), Peter Gennemark (Author) |
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Format: | Book |
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Elsevier,
2024-03-01T00:00:00Z.
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Online Access: | Connect to this object online. |
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