GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity

• প্রধান লেখক: Zilong Xiao (লেখক), Ziqing Yu (লেখক), Chaofeng Chen (লেখক), Ruizhen Chen (লেখক), Yangang Su (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: BMC, 2023-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Background The severe unfavorable effects of doxorubicin on the heart restrict its clinical usage. Numerous investigations document that cyclic GMP-AMP synthase (cGAS) activator of interferon genes (STING) cascade influences inflammation along with the immune response in a variety of diseas...