GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity

• Main Authors: Zilong Xiao (Author), Ziqing Yu (Author), Chaofeng Chen (Author), Ruizhen Chen (Author), Yangang Su (Author)
• Format: Knjiga
• Izdano: BMC, 2023-03-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Background The severe unfavorable effects of doxorubicin on the heart restrict its clinical usage. Numerous investigations document that cyclic GMP-AMP synthase (cGAS) activator of interferon genes (STING) cascade influences inflammation along with the immune response in a variety of diseas...