Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following In Vivo Delivery to Neonatal Mice

• Main Authors: John R. Counsell (Author), Rajvinder Karda (Author), Juan Antinao Diaz (Author), Louise Carey (Author), Tatiana Wiktorowicz (Author), Suzanne M.K. Buckley (Author), Shima Ameri (Author), Joanne Ng (Author), Julien Baruteau (Author), Filipa Almeida (Author), Rohan de Silva (Author), Roberto Simone (Author), Eleonora Lugarà (Author), Gabriele Lignani (Author), Dirk Lindemann (Author), Axel Rethwilm (Author), Ahad A. Rahim (Author), Simon N. Waddington (Author), Steven J. Howe (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Viral vectors are rapidly being developed for a range of applications in research and gene therapy. Prototype foamy virus (PFV) vectors have been described for gene therapy, although their use has mainly been restricted to ex vivo stem cell modification. Here we report direct in vivo transgene deliv...