HEXA-018, a Novel Inducer of Autophagy, Rescues TDP-43 Toxicity in Neuronal Cells

• मुख्य लेखकों: Shinrye Lee (लेखक), Myungjin Jo (लेखक), Hye Eun Lee (लेखक), Yu-Mi Jeon (लेखक), Seyeon Kim (लेखक), Younghwi Kwon (लेखक), Junghwa Woo (लेखक), Shin Han (लेखक), Ji Young Mun (लेखक), Hyung-Jun Kim (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The autophagy-lysosomal pathway is an essential cellular mechanism that degrades aggregated proteins and damaged cellular components to maintain cellular homeostasis. Here, we identified HEXA-018, a novel compound containing a catechol derivative structure, as a novel inducer of autophagy. HEXA-018...