HEXA-018, a Novel Inducer of Autophagy, Rescues TDP-43 Toxicity in Neuronal Cells

• Main Authors: Shinrye Lee (Author), Myungjin Jo (Author), Hye Eun Lee (Author), Yu-Mi Jeon (Author), Seyeon Kim (Author), Younghwi Kwon (Author), Junghwa Woo (Author), Shin Han (Author), Ji Young Mun (Author), Hyung-Jun Kim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The autophagy-lysosomal pathway is an essential cellular mechanism that degrades aggregated proteins and damaged cellular components to maintain cellular homeostasis. Here, we identified HEXA-018, a novel compound containing a catechol derivative structure, as a novel inducer of autophagy. HEXA-018...