CHK2 Promotes Metabolic Stress-Induced Autophagy through ULK1 Phosphorylation

• Main Authors: Ran Guo (Author), Shan-Shan Wang (Author), Xiao-You Jiang (Author), Ye Zhang (Author), Yang Guo (Author), Hong-Yan Cui (Author), Qi-Qiang Guo (Author), Liu Cao (Author), Xiao-Chen Xie (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reactive oxygen species (ROS) act as a signaling intermediate to promote cellular adaptation to maintain homeostasis by regulating autophagy during pathophysiological stress. However, the mechanism by which ROS promotes autophagy is still largely unknown. Here, we show that the ATM/CHK2/ULK1 axis in...