CHK2 Promotes Metabolic Stress-Induced Autophagy through ULK1 Phosphorylation

• Hoofdauteurs: Ran Guo (Auteur), Shan-Shan Wang (Auteur), Xiao-You Jiang (Auteur), Ye Zhang (Auteur), Yang Guo (Auteur), Hong-Yan Cui (Auteur), Qi-Qiang Guo (Auteur), Liu Cao (Auteur), Xiao-Chen Xie (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Reactive oxygen species (ROS) act as a signaling intermediate to promote cellular adaptation to maintain homeostasis by regulating autophagy during pathophysiological stress. However, the mechanism by which ROS promotes autophagy is still largely unknown. Here, we show that the ATM/CHK2/ULK1 axis in...