The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication.

• 主要な著者: Xiao-Dan Li (著者), Chao Shan (著者), Cheng-Lin Deng (著者), Han-Qing Ye (著者), Pei-Yong Shi (著者), Zhi-Ming Yuan (著者), Peng Gong (著者), Bo Zhang (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The flavivirus NS5 harbors both a methyltransferase (MTase) and an RNA-dependent RNA polymerase (RdRP). Both enzyme activities of NS5 are critical for viral replication. Recently, the full-length NS5 crystal structure of Japanese encephalitis virus reveals a conserved MTase-RdRP interface that featu...