The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication.

• Main Authors: Xiao-Dan Li (Author), Chao Shan (Author), Cheng-Lin Deng (Author), Han-Qing Ye (Author), Pei-Yong Shi (Author), Zhi-Ming Yuan (Author), Peng Gong (Author), Bo Zhang (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The flavivirus NS5 harbors both a methyltransferase (MTase) and an RNA-dependent RNA polymerase (RdRP). Both enzyme activities of NS5 are critical for viral replication. Recently, the full-length NS5 crystal structure of Japanese encephalitis virus reveals a conserved MTase-RdRP interface that featu...