The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication.

• Главные авторы: Xiao-Dan Li (Автор), Chao Shan (Автор), Cheng-Lin Deng (Автор), Han-Qing Ye (Автор), Pei-Yong Shi (Автор), Zhi-Ming Yuan (Автор), Peng Gong (Автор), Bo Zhang (Автор)
• Формат: ‌
• Опубликовано: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Предметы: article
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The flavivirus NS5 harbors both a methyltransferase (MTase) and an RNA-dependent RNA polymerase (RdRP). Both enzyme activities of NS5 are critical for viral replication. Recently, the full-length NS5 crystal structure of Japanese encephalitis virus reveals a conserved MTase-RdRP interface that featu...