A pharmacokinetic framework describing antibiotic adsorption to cardiopulmonary bypass devices

• Main Authors: Conor J. O'Hanlon (Author), Nick Holford (Author), Brian J. Anderson (Author), Mark Greaves (Author), Lee Blackburn (Author), Malcolm D. Tingle (Author), Jacqueline A. Hannam (Author)
• Format: Book
• Published: Wiley, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cardiopulmonary bypass (CPB) can alter pharmacokinetic (PK) parameters and the drug may adsorb to the CPB device, altering exposure. Cefazolin is a beta‐lactam antibiotic used for antimicrobial prophylaxis during cardiac surgery supported by CPB. Adsorption of cefazolin could result in ther...