A pharmacokinetic framework describing antibiotic adsorption to cardiopulmonary bypass devices

• Príomhchruthaitheoirí: Conor J. O'Hanlon (Údar), Nick Holford (Údar), Brian J. Anderson (Údar), Mark Greaves (Údar), Lee Blackburn (Údar), Malcolm D. Tingle (Údar), Jacqueline A. Hannam (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Wiley, 2024-08-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Abstract Cardiopulmonary bypass (CPB) can alter pharmacokinetic (PK) parameters and the drug may adsorb to the CPB device, altering exposure. Cefazolin is a beta‐lactam antibiotic used for antimicrobial prophylaxis during cardiac surgery supported by CPB. Adsorption of cefazolin could result in ther...