A pharmacokinetic framework describing antibiotic adsorption to cardiopulmonary bypass devices

Abstract Cardiopulmonary bypass (CPB) can alter pharmacokinetic (PK) parameters and the drug may adsorb to the CPB device, altering exposure. Cefazolin is a beta‐lactam antibiotic used for antimicrobial prophylaxis during cardiac surgery supported by CPB. Adsorption of cefazolin could result in ther...

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Main Authors: Conor J. O'Hanlon (Author), Nick Holford (Author), Brian J. Anderson (Author), Mark Greaves (Author), Lee Blackburn (Author), Malcolm D. Tingle (Author), Jacqueline A. Hannam (Author)
Formato: Livro
Publicado em: Wiley, 2024-08-01T00:00:00Z.
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