A pharmacokinetic framework describing antibiotic adsorption to cardiopulmonary bypass devices

• Автори: Conor J. O'Hanlon (Автор), Nick Holford (Автор), Brian J. Anderson (Автор), Mark Greaves (Автор), Lee Blackburn (Автор), Malcolm D. Tingle (Автор), Jacqueline A. Hannam (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2024-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Cardiopulmonary bypass (CPB) can alter pharmacokinetic (PK) parameters and the drug may adsorb to the CPB device, altering exposure. Cefazolin is a beta‐lactam antibiotic used for antimicrobial prophylaxis during cardiac surgery supported by CPB. Adsorption of cefazolin could result in ther...