High occurrence of <it>BRCA1 </it>intragenic rearrangements in hereditary breast and ovarian cancer syndrome in the Czech Republic

• Main Authors: Kuklova Jitka (Author), Pavlu Hana (Author), Horky Ondrej (Author), Damborsky Jiri (Author), Lukesova Miroslava (Author), Machackova Eva (Author), Vasickova Petra (Author), Kosinova Veronika (Author), Navratilova Marie (Author), Foretova Lenka (Author)
• Format: Book
• Published: BMC, 2007-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Alterations in the highly penetrant cancer susceptibility gene <it>BRCA1 </it>are responsible for the majority of hereditary breast and/or ovarian cancers. However, the number of detected germline mutations has been lower...