Crystal structures of Triosephosphate Isomerases from Taenia solium and Schistosoma mansoni provide insights for vaccine rationale and drug design against helminth parasites.

• Main Authors: Pedro Jimenez-Sandoval (Author), Eduardo Castro-Torres (Author), Rogelio González-González (Author), Corina Díaz-Quezada (Author), Misraim Gurrola (Author), Laura D Camacho-Manriquez (Author), Lucia Leyva-Navarro (Author), Luis G Brieba (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triosephosphate isomerases (TPIs) from Taenia solium (TsTPI) and Schistosoma mansoni (SmTPI) are potential vaccine and drug targets against cysticercosis and schistosomiasis, respectively. This is due to the dependence of parasitic helminths on glycolysis and because those proteins elicit an immune...