Microencapsulated Chitosan-Based Nanocapsules: A New Platform for Pulmonary Gene Delivery

• Những tác giả chính: Estefanía Fernández-Paz (Tác giả), Lucía Feijoo-Siota (Tác giả), Maria Manuela Gaspar (Tác giả), Noemi Csaba (Tác giả), Carmen Remuñán-López (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2021-08-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

In this work, we propose chitosan (CS)-based nanocapsules (NCs) for pulmonary gene delivery. Hyaluronic acid (HA) was incorporated in the NCs composition (HA/CS NCs) aiming to promote gene transfection in the lung epithelium. NCs were loaded with a model plasmid (pCMV-βGal) to easily evaluate their...