Microencapsulated Chitosan-Based Nanocapsules: A New Platform for Pulmonary Gene Delivery

• Główni autorzy: Estefanía Fernández-Paz (Autor), Lucía Feijoo-Siota (Autor), Maria Manuela Gaspar (Autor), Noemi Csaba (Autor), Carmen Remuñán-López (Autor)
• Format: Książka
• Wydane: MDPI AG, 2021-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

In this work, we propose chitosan (CS)-based nanocapsules (NCs) for pulmonary gene delivery. Hyaluronic acid (HA) was incorporated in the NCs composition (HA/CS NCs) aiming to promote gene transfection in the lung epithelium. NCs were loaded with a model plasmid (pCMV-βGal) to easily evaluate their...