An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.

• Main Authors: Meghan A Guzman (Author), Anastasia R Rugel (Author), Reid S Tarpley (Author), Sevan N Alwan (Author), Frédéric D Chevalier (Author), Dmytro P Kovalskyy (Author), Xiaohang Cao (Author), Stephen P Holloway (Author), Timothy J C Anderson (Author), Alexander B Taylor (Author), Stanton F McHardy (Author), Philip T LoVerde (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals, with a distinctly different mechanism of action,...