The Fab portion of immunoglobulin G has sites in the CL domain that interact with Fc gamma receptor IIIa

• Main Authors: Yuki Yamaguchi (Author), Natsumi Wakaizumi (Author), Mine Irisa (Author), Takahiro Maruno (Author), Mari Shimada (Author), Koya Shintani (Author), Haruka Nishiumi (Author), Rina Yogo (Author), Saeko Yanaka (Author), Daisuke Higo (Author), Tetsuo Torisu (Author), Koichi Kato (Author), Susumu Uchiyama (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The interaction between IgG and Fc gamma receptor IIIa (FcγRIIIa) is essential for mediating immune responses. Recent studies have shown that the antigen binding fragment (Fab) and Fc are involved in IgG-FcγRIII interactions. Here, we conducted bio-layer interferometry (BLI) and isothermal titration...