Exploring BSEP Inhibition-Mediated Toxicity with a Mechanistic Model of Drug-Induced Liver Injury

• Hoofdauteurs: Jeffrey L Woodhead (Auteur), Kyunghee eYang (Auteur), Scott Q Siler (Auteur), Paul Brent Watkins (Auteur), Kim L.R. Brouwer (Auteur), Hugh A Barton (Auteur), Brett A Howell (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2014-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have previously constructed and validated a model of bile acid disposition within DILIsym®, a mechanistic model of DILI...