Exploring BSEP Inhibition-Mediated Toxicity with a Mechanistic Model of Drug-Induced Liver Injury

• Asıl Yazarlar: Jeffrey L Woodhead (Yazar), Kyunghee eYang (Yazar), Scott Q Siler (Yazar), Paul Brent Watkins (Yazar), Kim L.R. Brouwer (Yazar), Hugh A Barton (Yazar), Brett A Howell (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2014-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have previously constructed and validated a model of bile acid disposition within DILIsym®, a mechanistic model of DILI...