Exploring BSEP Inhibition-Mediated Toxicity with a Mechanistic Model of Drug-Induced Liver Injury

• Main Authors: Jeffrey L Woodhead (Author), Kyunghee eYang (Author), Scott Q Siler (Author), Paul Brent Watkins (Author), Kim L.R. Brouwer (Author), Hugh A Barton (Author), Brett A Howell (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have previously constructed and validated a model of bile acid disposition within DILIsym®, a mechanistic model of DILI...