Formulation of Bioerodible Ketamine Microparticles as an Analgesic Adjuvant Treatment Produced by Supercritical Fluid Polymer Encapsulation

• Main Authors: Felicity Y. Han (Author), Andrew K. Whittaker (Author), Steven M. Howdle (Author), Andrew Naylor (Author), Anjumn Shabir-Ahmed (Author), Cheng Zhang (Author), Maree T. Smith (Author)
• Format: Book
• Published: MDPI AG, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pain is inadequately relieved by escalating doses of a strong opioid analgesic such as morphine in up to 25% of patients with cancer-related severe pain complicated by a neuropathic (nerve damage) component. Hence, there is an unmet medical need for research on novel painkiller strategies. In the pr...