Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity

• Main Authors: Alessandro A. Bailetti (Author), Lenny J. Negrón-Piñeiro (Author), Vishal Dhruva (Author), Sneh Harsh (Author), Sean Lu (Author), Aisha Bosula (Author), Erika A. Bach (Author)
• Format: Book
• Published: The Company of Biologists, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders that cause excessive production of myeloid cells. Most MPN patients have a point mutation in JAK2 (JAK2V617F), which encodes a dominant-active kinase that constitutively triggers JAK/STAT signaling. In Drosophila, this pathway is...