Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity

• Principais autores: Alessandro A. Bailetti (Autor), Lenny J. Negrón-Piñeiro (Autor), Vishal Dhruva (Autor), Sneh Harsh (Autor), Sean Lu (Autor), Aisha Bosula (Autor), Erika A. Bach (Autor)
• Formato: Livro
• Publicado em: The Company of Biologists, 2019-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders that cause excessive production of myeloid cells. Most MPN patients have a point mutation in JAK2 (JAK2V617F), which encodes a dominant-active kinase that constitutively triggers JAK/STAT signaling. In Drosophila, this pathway is...