Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity

• मुख्य लेखकों: Alessandro A. Bailetti (लेखक), Lenny J. Negrón-Piñeiro (लेखक), Vishal Dhruva (लेखक), Sneh Harsh (लेखक), Sean Lu (लेखक), Aisha Bosula (लेखक), Erika A. Bach (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2019-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders that cause excessive production of myeloid cells. Most MPN patients have a point mutation in JAK2 (JAK2V617F), which encodes a dominant-active kinase that constitutively triggers JAK/STAT signaling. In Drosophila, this pathway is...