Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients-A Controlled Clinical Trial

• Main Authors: Philipp Simon (Author), David Petroff (Author), David Busse (Author), Jana Heyne (Author), Felix Girrbach (Author), Arne Dietrich (Author), Alexander Kratzer (Author), Markus Zeitlinger (Author), Charlotte Kloft (Author), Frieder Kees (Author), Hermann Wrigge (Author), Christoph Dorn (Author)
• Format: Bog
• Udgivet: MDPI AG, 2020-12-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and tissue pharmacokinetics of meropenem. Methods: Obese (body mass index (BMI) ≥ 35 kg/m²) and age-/sex-matched nonobese (18.5 kg/m² ≥ BMI ≤ 30 kg/m<sup&g...