NPV-BSK805, an Antineoplastic Jak2 Inhibitor Effective in Myeloproliferative Disorders, Causes Adiposity in Mice by Interfering With the Action of Leptin

• 主要な著者: Magalie Haissaguerre (著者), Amandine Ferriere (著者), Samantha Clark (著者), Omar Guzman-Quevedo (著者), Antoine Tabarin (著者), Daniela Cota (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The pathophysiology of body weight gain that is observed in patients suffering from myeloproliferative neoplasms treated with inhibitors of the janus kinase (Jak) 1 and 2 pathway remains unknown. Here we hypothesized that this class of drugs interferes with the metabolic actions of leptin, as this h...