NPV-BSK805, an Antineoplastic Jak2 Inhibitor Effective in Myeloproliferative Disorders, Causes Adiposity in Mice by Interfering With the Action of Leptin

• Prif Awduron: Magalie Haissaguerre (Awdur), Amandine Ferriere (Awdur), Samantha Clark (Awdur), Omar Guzman-Quevedo (Awdur), Antoine Tabarin (Awdur), Daniela Cota (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The pathophysiology of body weight gain that is observed in patients suffering from myeloproliferative neoplasms treated with inhibitors of the janus kinase (Jak) 1 and 2 pathway remains unknown. Here we hypothesized that this class of drugs interferes with the metabolic actions of leptin, as this h...