NPV-BSK805, an Antineoplastic Jak2 Inhibitor Effective in Myeloproliferative Disorders, Causes Adiposity in Mice by Interfering With the Action of Leptin

• Auteurs principaux: Magalie Haissaguerre (Auteur), Amandine Ferriere (Auteur), Samantha Clark (Auteur), Omar Guzman-Quevedo (Auteur), Antoine Tabarin (Auteur), Daniela Cota (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The pathophysiology of body weight gain that is observed in patients suffering from myeloproliferative neoplasms treated with inhibitors of the janus kinase (Jak) 1 and 2 pathway remains unknown. Here we hypothesized that this class of drugs interferes with the metabolic actions of leptin, as this h...