Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning

• Main Authors: Dong Liang (Author), Chen Yu (Author), Zhao Ma (Author), Xingye Yang (Author), Zhenzhen Li (Author), Xuhui Dong (Author), Xiaojun Qin (Author), Lupei Du (Author), Minyong Li (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Head and neck squamous cell carcinoma (HNSCC) is one of the most common human cancers; however, its outcome of pharmacotherapy is always very limited. Herein, we performed a batch query in the connectivity map (cMap) based on bioinformatics, queried out 35 compounds with therapeutic potential, and s...