Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning

• Egile Nagusiak: Dong Liang (Egilea), Chen Yu (Egilea), Zhao Ma (Egilea), Xingye Yang (Egilea), Zhenzhen Li (Egilea), Xuhui Dong (Egilea), Xiaojun Qin (Egilea), Lupei Du (Egilea), Minyong Li (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2022-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Head and neck squamous cell carcinoma (HNSCC) is one of the most common human cancers; however, its outcome of pharmacotherapy is always very limited. Herein, we performed a batch query in the connectivity map (cMap) based on bioinformatics, queried out 35 compounds with therapeutic potential, and s...